Erythromycin sexually transmitted diseases

Erythromycin is also an effective alternative to tetracycline for the treatment of adult chlamydial sexually transmitted disease. Adults should receive 2 g of erythromycin daily in four divided doses for at least 7 days. Trachoma and inclusion conjunctivitis in older children or adults... 

Azithromycin achieves high concentrations in tissues relative to those in plasma. It remains largely unmetabolised and is excreted in the bile and faeces (t) 50h). Azithromycin is used to treat respiratory tract and soft tissue infections, and sexually transmitted diseases, especially genital Chlamydia infections. Gastrointestinal effects (9%) are less than with erythromycin but diarrhoea, nausea and abdominal pain occur. In view of its high hepatic excretion use in patients with liver disease should be avoided. Interactions see erythromycin (above). 

Erythromycin-A (EM) obtained from S. erythreus has utility in a wide variety of Gm+ infections, including sexually transmitted diseases such as syphilis, chlamydia, and gonorrhea. The drug can be considered for penicillin-allergic patients. In an outbreak of Legionnaire s disease, EM was found to be the only antibiotic to reverse the morbidity of this new disease. 

Azithromycin is a macrolide (erythromycin, clarithromycin, and azithromycin) that interferes with microbial protein synthesis. It is indicated in the following conditions. Adults treatment of infections of the respiratory tract, acute bacterial sinusitis, acute bacterial exacerbations of COPD, community-acquired pneumonia, Mycobacterium avium complex, pelvic inflammatory disease, pharyngitis/tonsilli-tis, skin and skin structure infections, and sexually transmitted diseases caused by susceptible organisms. Children treatment of acute bacterial sinusitis, acute otitis media caused by susceptible organisms, community-acquired pneumonia, pharyngitis/tonsillitis caused by S. pyogenes in patients who cannot use first-line therapy. 

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