Erythrocyte Indices

The use of infrared is not limited to p structure detection, however. The erythrocyte study reported here clearly illustrates the information available when spectra are taken in D20. Optical changes permit one to estimate the extent and rapidity of proton exchange in proteins and hence to estimate the availability of peptide bonds to water protons as well as the contributions from random coil and a-helical conformations. The results with erythrocytes indicate that about two-thirds to three-fourths of the protein amide groups are freely accessible to water and that most of the protein exists in an open, mostly random, conformation. The fraction of non-exchangeable protons agrees reasonably well with the helical content determined by ORD. 

From c. 1900 experiments, many of them with mammalian erythrocytes, indicated cells were selectively permeable to a range of low molecular weight neutral solutes. If molecules with similar structures were added to the suspension medium, entry of the test solute might be reduced. 

Bull BS, Elashoff RM, Heilbron DC, et al. A study of various estimators for the derivation of quality control procedures from patient erythrocyte indices. Am J Clin Pathol 1974 61 473-81. 

Blood Cell Count A count of the number of leukocytes and erythrocytes per unit volume in a sample of venous blood. A complete blood count (CBC) also includes measurement of the hemoglobin, hematocrit, and erythrocyte indices, [nih]... 

Erythrocyte Indices Quantification of size and ceU hemoglobin content or concentration of the erythrocyte, usually derived from erythrocyte count, blood hemoglobin concentration, and hematocrit. Includes the mean ceU volume (MCV), mean ceU hemoglobin (MCH), and mean ceU hemoglobin concentration (MCHC). Use also for ceU diameter and thickness, [nih]... 

A photograph of separated erythrocytes, indicated by white arrows, (b) Schematic diagram of the erythrocyte alignment and separation (Adapted from Ref. [24]). (c) Leukocyte enrichment from whole blood. As smaller, more flexible erythrocytes seek the faster flow region in the center of the channel lumen and collide with... 

C) Laboratory tests. A complete blood count including a leukocyte count with differential, a quantitative thrombocyte count, hematocrit, hemoglobin, erythrocyte count and erythrocyte indices (MCV, MCH, MCHC). The results of these tests shall be reviewed by the examining physician. 

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