Erica andevalensis

Reyes et al. [98] have investigated the antiulcerogenicity of the flavonoid fraction (ethylacetate extract) of Erica andevalensis, a species endemic to southern of Spain. Oral treatment with the purified extract of the major flavonoid, myricetin-3-O-D-galactoside, was found to be effective against gastric ulceration induced by cold-restraint stress, pyloric ligature, and absolute ethanol in rats. 

Concerning ulcers induced by absolute ethanol, pretreatment with silymarin stimulated mucus secretion, but did not modify the concentration of total proteins and hexosamines [99]. By contrast, in the same experimental model, Reyes et al. [98] found that mucus amount was not modified by the ethylacetate extract of Erica andevalensis, although there was an increase in the concentration of its components. Perez-Guerrero et al. [113] showed that rutin, the glycoside of quercetin, has a protective effect, although it did not induce any changes in the amount of mucus or in its glycoprotein content. 

In this regard, several investigators have proven that some flavonoids show interesting effects upon the wall of the smallest blood vessels and particularly on the perivascular tissue. This is the case of Erica andevalensis, whose ethyl acetate extract showed a marked dose-dependent effect on the mucosal vascular permeability against the proinflammatory mediator histamine [98]. 

---