ErbB receptors intracellular

In addition to the approaches covered in a recent review [20], the first comprehensive model covering receptor dimerization and internalization has been recently described [21], In this work, the authors use direct time-dependent measurement of the phosphorylation of the four ErbB receptor species, as well as protein quantitation to develop a comprehensive mechanistic model of receptor dimerization and internalization. Once this comprehensive, quantitative framework was developed, the authors were able to show that receptor dephosphorylation, a key step in the downregulation of ErbB-driven signaling, was restricted to intracellular compartments. 

Waterman, H., I. Sabanai, B. Geiger, and Y. Yarden. Alternative intracellular routing of ErbB receptors may determine signaling potency. J Biol Chem. 273 13819-13827.1998. 

---