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ErbB receptors breast cancer association

Trastuzumab (Herceptin) is a humanized monoclonal antibody against the HER2/neu (ErbB-2) member of the epidermal growth factor family of cellular receptors. The internal domain of the HER2/neu glycoprotein encodes a tyrosine kinase that activates downstream signals and enhances metastatic potential and inhibits apoptosis. HER2/neu is overexpressed in up to 30% of breast cancers and is associated with clinical resistance to cytotoxic and hormone therapy. A number of mechanisms of action have... [Pg.701]

See other pages where ErbB receptors breast cancer association is mentioned: [Pg.604]    [Pg.1011]    [Pg.34]    [Pg.34]    [Pg.604]    [Pg.1011]    [Pg.125]    [Pg.2340]    [Pg.154]    [Pg.797]    [Pg.30]    [Pg.34]    [Pg.81]    [Pg.208]    [Pg.472]    [Pg.472]    [Pg.9]    [Pg.30]   
See also in sourсe #XX -- [ Pg.32 , Pg.33 , Pg.34 , Pg.35 , Pg.36 ]



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ErbB receptors

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