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ErbB receptors characterization

Several cancer cell types are characterized by expressing a truncated EGF receptor. The related viral oncogene, V-er B, also encodes a truncated receptor which lacks most of the extracellular domain (the EGF receptor is also known as C-erbB). Mutant receptors that display inappropriate constitutive activity can lead to cellular transformation, due to the continuous generation of mitogenic signal. [Pg.287]

Kraus, M.H. Issing, W. Miki, T. Popescu, N.C. Aaronson, S.A. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. USA, 86, 9193-9197 (1989)... [Pg.594]

See other pages where ErbB receptors characterization is mentioned: [Pg.327]    [Pg.253]    [Pg.254]    [Pg.8]    [Pg.28]    [Pg.28]    [Pg.46]    [Pg.62]    [Pg.8]    [Pg.569]    [Pg.100]    [Pg.120]    [Pg.870]    [Pg.592]    [Pg.358]    [Pg.569]    [Pg.189]   
See also in sourсe #XX -- [ Pg.26 , Pg.27 , Pg.28 ]



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ErbB receptors

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