Equation Nernst-Noyes

Interestingly, Shchukarev equation, which included the separation surface area and equated the concentration on the inner side of the diffusion layer to the solubility value, was published in April 1896. But it was not noticed abroad where the priority was ascribed to A. Noyes and W. Witney who published their equation without considering the area only by the end of 1897. In 1900 their error was corrected, and in 1904 Nernst expanded the upgraded equation on all heterogeneous processes. For this reason this model mass transfer subsequently was treated as Nernst-Noyes equation. 

The dissolution of drugs has been described by the Noyes-Whitney equation as later modified by Nernst and Brunner [21, 22] ... 

The kinetics of the dissolution process obeys the Noyes and Whitney equation [26], revised by Nernst and Brunner ... 

The dissolution rate (dC/dt) of a pure drug compound is represented by an equation based on the work of Noyes, Whitney, Nernst, and Brunner (4-6), which is in turn based on earlier observations made by Schiikarew in 1891 (7) ... 

Dissolution rate, or simply dissolution, refers to the rate at which a compound dissolves in a medium. The dissolution rate may be expressed by the Nernst-Brunner diffusion layer form of the Noyes-Whitney equation ... 

With very few exceptions, dissolution of the drug substance in the GI tract milieu is a prerequisite for drug absorption following oral administration. For Class II compounds, the rate-limiting factor in their intestinal absorption is dissolution /solubility [23-25]. Hence, in-depth understanding of this process is essential in the oral delivery of low-solubility compounds. Factors governing the dissolution process can be directly identified from the following equation, based on the Nernst-Brunner and Levich modifications of the Noyes-Whitney model [26-28] ... 

Crystal growth can be considered to be a reverse dissolution process. The diffusion theories of Noyes and Whitney and Nernst consider that matter is deposited continuously on a crystal face at a rate proportional to the difference of concentration between the surface and the bulk solution. So an equation for crystallization can be proposed in the form... 

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