Epipodophyllotoxin glycoside

Podophyllotoxin is used externally to treat condylomata acuminata (soft warts). Etoposide is a semi-synthetic derivative of epipodophyllotoxin glycoside, currently being used for the treatment of cancer. 

Tafluposide (F 11782) is an epotoside (epipodophyllotoxin) derivative (cf. Chapter 4) where the two hydroxyls of the glycosidic moiety are acylated with pentafluorophenoxyacetic acid (Figure 8.7). It has been demonstrated that tafluposide does not act as a prodrug of epotoside, but it has a unique mechanism of interaction with both topoisomerases I and... 

The epipodophyllotoxins (Fig. 42.38) are semisynthetic glycosidic derivatives of podophyllotoxin, the major component of the resinous podophyllin isolated from the dried roots of the American mandrake or mayapple plant (Podophyllum peltatum). Although these compounds are capable of binding to tubulin and inhibiting mitosis, their primary mechanism of antineoplastic action is poisioning topoisomerase II, a mechanism that they share... 

The highly active and widely used cancer chemotherapeutic epipodophyllotoxins etopo-side and teniposide are also MDP-containing glycosides metabolized primarily by CYP3A4, and to a lesser extent by CYP2E1 and CYP1A2... 

---