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Epilepsies definition

Browne TR, Holmes GL. Epilepsy definitions and background. In Handbook of Epilepsy, 2nd Ed. New York Lippincott Williams Wilkins, 1999 1-18. [Pg.794]

In addition to epilepsy, neuronal death due to the toxic effects of glutamate has also been implicated in cerebral ischaemia associated with multi-infarct dementia and possibly Alzheimer s disease. With the plethora of selective excitatory amino acid receptor antagonists currently undergoing development, some of which are already in clinical trials, one may expect definite advances in the drug treatment of neurodegenerative disorders in the near future. [Pg.60]

Epilepsy is a chronic often progressive disorder of the central nervous system (CNS). Periodic and unpredictable epileptic seizures caused by the abnormal electrical discharge of neurones in various anatomic structures of the CNS is the characteristic feature. This is an approximate definition based on international classifications of seizures and syndromes which take into account the extremely variable clinical and electroencephalographic expression of the disease. The annual incidence of epilepsy is an estimated 20-70 cases per 100,000 inhabitants with a prevalence of 0.4-0.8%. Globally, incidence is higher during childhood, remaining rather stable... [Pg.685]

It is well established that mitochondrial function defects are not severe until the proportion of mutant mtDNA reaches a high level, which forms the basis of the concept of the threshold effect. In skeletal muscle, the level of the A3243G mutation is related to the severity of strokelike episodes, epilepsy, and dementia in patients with MELAS syndrome (C6, H14, PI). Similarly, the level of the A8344G mutation is correlated with the degree of cerebellar ataxia and myoclonus in patients with MERRF syndrome (C6). Thus, molecular genetic analysis of mtDNA mutations in muscle biopsies usually provides more definitive diagnosis of... [Pg.88]

Febrile convulsions generally occur between six months and 3 years of age. A family history of epilepsy is not definitely associated with an increased risk of febrile convulsions, but if they happen they are more likely to recur. The younger the age group the higher the risk of recurrence (especially <1 year). By the age of 8 years only 3% of children who have had a febrile convulsion will have developed epilepsy and the two events seem unrelated. [Pg.401]

The definition of an antiepileptogenic compound is one that prevents or slows the process of developing epilepsy (Cole and Dichter, 2002). Several experimental studies have aimed at preventing epileptogenesis in animal models, including SE and kindling models, by administering AEDs. Some have mild or questionable effects, and others are without effect even if they neuroprotect (Walker et al., 2002). [Pg.103]


See other pages where Epilepsies definition is mentioned: [Pg.42]    [Pg.325]    [Pg.448]    [Pg.337]    [Pg.190]    [Pg.431]    [Pg.431]    [Pg.593]    [Pg.179]    [Pg.399]    [Pg.295]    [Pg.401]    [Pg.807]    [Pg.229]    [Pg.1028]    [Pg.1034]    [Pg.25]    [Pg.184]    [Pg.217]    [Pg.122]    [Pg.82]    [Pg.95]    [Pg.263]   
See also in sourсe #XX -- [ Pg.445 ]

See also in sourсe #XX -- [ Pg.319 ]




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Epilepsies

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