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Epigenetic Agents

SuganumaT, Workman JL (2008) Crosstalk among histone modifications. Cell 135 604-607 Jones P (2012) Development of second generation epigenetic agents. Med Chem Comm 3 135... [Pg.148]

Many anticancer agents currently in use, including chemotherapeutic drugs and radiation, are potent inducers of apoptosis and cell-cycle arrest. It is believed that induction of these molecular pathways is central to the efficacy of such agents [1]. Genetic and epigenetic alterations that contribute to tumorigenesis... [Pg.317]

To Provide Mechanistic Insight. For example, if an agent is negative in a wide range of genetic toxicity screens, but still produces tumors in animals, then one could hypothesize that an epigenetic mechanism was involved. [Pg.59]

Epigenetic carcinogens. These are (i) tumor promoters mitogenic agents, causing proliferation of initiated cells. Examples are phorbol esters and peroxisome proliferators ... [Pg.273]

DNA-damaging carcinogens Epigenetic carcinogens Progressor agents... [Pg.285]

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Epigenetic

Epigenetics

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