Epidermal molecular weight

Nickel is localized predominantly in the epidermal and subepidermal of the leaves. However, in leaves of some hyperaccumulator plants such as T. caerulescens and T. goesingense, Ni and Zn are found mainly in vacuoles (Salt and Kramer, 2000). Trace elements also are inactivated in the vacuoles as high-affinity low-molecular-weight metal chelators (such as Cd-phytochelatin complex), providing plants with trace element tolerance. Some Ni in leaves is found to be associated with cell wall pectates as well. 

Pugh WJ, Degim IT, Hadgraft J (1996) Epidermal permeability-penetrant structure relationships 4. QSAR of permeant diffusion across human stratum corneum in terms of molecular weight, H-bonding and electronic charge. Int J Pharm 197 203-211. 

Cubilin is a glycoprotein with a molecular weight of460 kDa (A1, K21) with 27 CUB domains (subunits of complement Clr/Cls, epidermal growth factor (EGF),... 

Of the various DTH responses, contact hypersensitivity possibly affects the greatest number of individuals. It is a common occupational health problem in a variety of industrial settings and it can occur following chemical exposures in the home and in the environment. One of the most recognized contact hypersensitivity reactions affecting many people is that which develops in response to cutaneous exposure to poison ivy (pentadecacatechol). Contact hypersensitivity reactions are initiated by topical exposure to the skin (often by a small molecular weight chemical), and the subsequent response is primarily epidermal. 

Using the mouse ear epidermis in vitro as an assay system and counting mitoses arrested by Colcemid in the medium over a 4-hour period, the same workers showed that the epidermal chalone is not species specific, but is tissue specific (B49, B52) that it requires epinephrine for effect (B48), and perhaps glucocorticoids (B50) and that it is most likely a glycoprotein with a molecular weight of about 30,000 (B25). This work has been recently reviewed and the additional comment made that epidermal chalone is present in active form in human urine (B45). 

Thrombomodulin 1009 Transmembrane glycoprotein of 75-kD molecular weight containing 6 repeated domains homologous with epidermal growth factor Recombinant thrombomodulin Dako 1 50 HIER... 

The chief value of this study is to throw further light on the fibrous protein which forms the greater part of the epidermal cell. The protein is highly asymmetric, it has a typical a. structure, and in solution in urea/bisulfite it has a molecular weight of the order of 60,000. When reprecipitated and dried the extracted protein shows a lack of cohesion between its particles, while within the tissue much of the protein behaves as if the particles were extensively linked together. 

Trichome PPO appears to be an example of an evolutionary modification of an existing plant enzyme for use as an insect defense mechanism. PPO enzymes, of molecular weight 45,000, are localized in the thylakoid and are nearly ubiquitous in tissues of plants (12,18.). Unlike other known nuclear encoded chloroplast proteins, the 45 kD thylakoid PPO, whose function is unknown, is translated at its mature size of 45 kD, and does not possess a transit peptide sequence (19). In contrast, the 5 9 kD trichome PPO is translated as a 67 kD precursor and localized in the leucoplasts of trichome and outer epidermal cells. Immunological and primary sequence similarities between the 59 kD trichome PPO and the 45 kD thylakoid PPO underscore the close evolutionary relationship between these two proteins. The apparent advantage of the very high concentration of PPO in the trichome is the high initial rate of catalysis which results upon trichome rupture, facilitating the entrapment of mobile insects. 

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