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Epidermal growth factors ErbB signaling

Trastuzumab (Herceptin) is a humanized monoclonal antibody against the HER2/neu (ErbB-2) member of the epidermal growth factor family of cellular receptors. The internal domain of the HER2/neu glycoprotein encodes a tyrosine kinase that activates downstream signals and enhances metastatic potential and inhibits apoptosis. HER2/neu is overexpressed in up to 30% of breast cancers and is associated with clinical resistance to cytotoxic and hormone therapy. A number of mechanisms of action have... [Pg.701]

See other pages where Epidermal growth factors ErbB signaling is mentioned: [Pg.604]    [Pg.99]    [Pg.86]    [Pg.34]    [Pg.472]    [Pg.472]    [Pg.283]    [Pg.160]    [Pg.429]    [Pg.248]    [Pg.34]    [Pg.604]    [Pg.566]    [Pg.154]    [Pg.26]    [Pg.900]    [Pg.472]    [Pg.472]    [Pg.78]    [Pg.278]    [Pg.186]    [Pg.35]    [Pg.43]    [Pg.218]    [Pg.410]   
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Epidermal

Epidermal growth factor

Signaling factor

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