Eosinophils cytokines elaborated

Human eosinophils were found to elaborate chemoattractants for lymphocytes (Lim etal., 1994). Eosinophils contained mRNA transcripts for LCF and RANTES detectable by RT-PCR amplification and released bioactive LCF neutralized both by antibodies to LCF and CD4, the LCF receptor on migrating lymphocytes (Lim et al., 1994). In addition, eosinophils released RANTES protein detectable by ELISA and by functional lymphocyte migration assay. Thus, eosinophils are a source of cytokines capable of specificaUy affecting the function of CD4 lymphocytes. The recognition that eosinophils are a source of lymphocyte chemoattractant activity identifies an additional mechanism whereby eosinophils may contribute to lymphocyte responses. Since eosinophils are recruited early in certain allergic inflammatory immune responses, the release of LCF and RANTES by human eosinophils may enable eosinophils to recruit and activate not only other eosinophils but also CD4 lymphocytes (Lim etal., 1994). 

Lim, K., Wan, H., Resnick, M., Wong, D., Cruikshank, WL, Center, D. and Weller, P. (1995). Human eosinophils elaborate lymphocyte chemoattractant cytokines RANTES and lymphocyte chemoattractant factor. Int. Arch. Allergy Appl Immunol in press. 

Weller, P.F. (1992). Eicosanoids, cytokines and other mediators elaborated by eosinophils. In Eosinophils Biological and Clinical Aspects (eds. S. Makino and T. Fukuda), pp. 125-154. CRC Press, Boca Eaton. 

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