Enzymes controlled release

Supporting material for clinical analysis, cell immobilization Cell encapsulation and immobilization, immobilization of enzymes, controlled release, injectable microcapsules Microencapsulation, thermoreversible gelation Lubrication applications... 

Microstructure and viscosity are dependent on the chemical composition Used as immobilization matrices for cells and enzymes, controlled release of bioactive substances, injectable microcapsules for treating neurodegenerative and hormone deficiency diseases Lacks yield value... 

V. Subr, J. KopeCek, J. Pohl, M. Baudys and V. Kostka, Cleavage of oligopeptide side-chains in N-(2-hydroxypropyl)metha-crylamide copolymers by mixtures of lysosomal enzymes, /. Control. Release, 8,133-140 (1988). 

In open fibers the fiber wall may be a permselective membrane, and uses include dialysis, ultrafiltration, reverse osmosis, Dorman exchange (dialysis), osmotic pumping, pervaporation, gaseous separation, and stream filtration. Alternatively, the fiber wall may act as a catalytic reactor and immobilization of catalyst and enzyme in the wall entity may occur. Loaded fibers are used as sorbents, and in ion exchange and controlled release. Special uses of hoUow fibers include tissue-culture growth, heat exchangers, and others. 

Robert Langer, Polymer Systems for Controlled Release of Macromolecules, Immobilized Enzyme Medical Bioreactors, and Tissue Engineering J. J. Linderman, P. A. Mahama, K. E. Forsten, and D, A. Lauffenburger, Diffusion and Probability in Receptor Binding and Signaling Rakesh K. Jain, Transport Phenomena in Tumors... 

Acid-catalyzed matrices, kinetics of controlled release, 170-179 Active targeting, definition, 276 Adenosine deaminase, activity of polyethylene glycol modified enzymes, 98-99 Adjuvax... 

CK Sim, K Park. Examination of drug release from enzyme-digestible swelling hydrogels. Proc Int Symp Controlled Release Bioact Mater 16 219-220, 1989. 

Poly-j3-malate is readily degraded completely to L-malic acid under both acid and base conditions [108], and it can also be hydrolyzed by enzymes within the cell [105,106]. Recently, several bacteria were isolated which were able to utilize poly-/i-malate as sole carbon source for growth [109]. Because the polymer is biodegradable and bioadsorbable, it is of considerable interest for pharmaceutical applications, especially in controlled-release drug delivery systems [97,98]. Chemical routes to poly-/ -malate are expected to provide materials with various properties [110]. 

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery, J. Controlled Release 1999, 62, 25-31. 

Initially, the sol gel compositions were optimized using Congo red dye as the dopant because of its optical properties. This facilitates monitoring of the release process by optical spectroscopy. Next, the gels were evaluated for their stabilization and release of subtilisin. These sol gel matrices bring about controlled release of the encapsulated enzyme molecules as a response to a change in the water content of the medium (Figure 2.20).15... 

Langer, R. 1994. Polymer systems for controlled release of macromolecnles, immohilized enzyme medical hioreactors, and tissne engineering. In Advances in Chemical Engineering, vol. 19. San Diego Academic Press 1-50. 

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