Enzyme Field Effect Transistors

S.V. Dzyadevych, A.P. Soldatkin, Y.I. Korpan, V.N. Arkhypova, A.V. El skaya, J.-M. Chovelon, C. Martelet and N. Jaffrezic-Renault, Biosensors based on enzyme field-effect transistors for determination of some substrates and inhibitors, Anal. Bioanal. Chem., 377 (2003) 496-506. 

Dzyadevich, S. V. (1999). Soldatkin application of enzyme field-effect transistors for determination of glucose concentrations in blood serum. Biosens Bioelectron 14, 283-287. 

Fig. 16 Enzyme field-effect transistor (ENFET) based on LbL assembly of enzymes with Mn02 nanoparticle and polyelectrolyte on the surface of ion-sensitive field-effect transistor (ISFET)...

MIS field-effect transistors (MISFETs) and enzyme field-effect transistors (ENFETs) based on conducting polymers have also been fabricated. A schematic diagram of such a device is shown in Figure 13.12. Janata and co-workers have investigated the electrical properties... 

Furthermore, the gate area of pH-sensitive ISFET s (ion-sensitive field-effect transistor) has been covered with pH changing enzymes, such as urease and )8-lactamase [12]. Furthermore, ATPase, glucose oxidase, and trypsin were used for ATP, glucose, and peptide ENFET s (enzyme-field-effect transistor). 

Combined (e.g., transducer and analyte) amperometric urea sensor, immunologically sensitized field-effect transistor (IMFET), enzyme field-effect transistor (ENFET)... 

En me sensors involving semiconductors are called enzyme field-effect transistors, ENFET, and, as their name implies, exploit the association of an en me with a field-effect transistor (Fl. The transistor has a metal oxide semiconductor field-effect transistor (MOSFET) structure, which is constructed from, for example, a p-type silicon substrate (Figure 4.30). This central channel is defined by placing two n-type semiconducting zones, called the source and the drain, on opposite sides of the substrate. A metallic gate is isolated from the channel by a thin insulating film (Si02), which also covers the upper face of the substrate. 

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