Enzyme catalysis relaxation concept

The results of experiments on acid-base phosphorylation (the pH jump-induced ATP synthesis) performed by isolated or membrane-bound H ATPases could be interpreted on the basis of the relaxation concept of enzyme catalysis. This concept allows us to suggest a model for ATP synthesis consistent with all the experimental data considered above. It has been proposed, in [182-187, 190, 191], that the fast ionization of certain acid... 

Independently of McClare, similar ideas have been put forward by one of us [1, 2] who elaborated on the concept of molecular machines for enzyme catalysis and energy transduction in chemical and biochemical systems. A central point of this concept was founded on the notion of the crucial role of the conformational relaxation of biopolymers in catalyzing biochemical processes. We will consider the application of this relaxation concept to enzymo-logy and bioenergetics in Chapters 4 and 5. We now focus our attention on the general principles of energy transduction by molecular machines. 

The immediate relation to the relaxation concept of enzyme catalysis [3,4, 20, 21] is the theory of rate processes that has been developed by Fain [35]. In this paper. Fain states that the conventional approach to the kinetics of chemical reactions does not hold true for highly ordered macromolecular structures. The traditional approach to the problem implies that all vibrational modes undergo fast relaxation to thermal equilibrium. In the conventional approach to chemical kinetics, the changes in electronic states and nuclear vibration amplitudes were considered separately. Fain has proposed the self-consistent description of simultaneous changes taking place in the... 

I.5. ATP Synthesis from ADP and Pg as Considered from the Viewpoint of the Relaxation Concept of Enzyme Catalysis... 

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