Enteric-coated dosage form, administration

Which of the following is unlikely to be associated with oral drug administration of an enteric-coated dosage form ... 

Figure 11 Titer of anti-short ragweed IgG antibodies, treated and placebo. The amount of IgG was increased by administration of the enteric-coated dosage form. Without enteric film coating the antibodies would have been destroyed. (Source Ref. 68.)...

Drugs are administrated by intravenous routes or ex-travascular routes including oral, sublingual, subcutaneous, intramuscular, rectal (by enema or suppository), and transdermal. Available dosage forms include suspensions, immediate-release capsules or tablets, sustained-release capsules or tablets, and enteric-coated capsules or tablets that resist dissolution in the acidic pfi of the stomach. 

Modified-release preparations are discussed for several reasons. At first, a pharmacist should know that such modifications on active substance release exist, and that he may dispense medicines with a specific release profile. Secondly, some active substances are only available as a modified-release preparation. Thirdly, the administration of a modified active substance release profile fi-om a tablet might be due to the properties of the active substance. These are some aspects that must be considered before such a tablet is crushed or a capsule is emptied. Enteric-coated tablets and capsules are not described as modified release preparations in the Ph. Eur. [6] but the same care must be taken not to damage the coat when using it for the preparation of other dosage forms. 

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