Enhancement of the Endogenous Cannabinoid Tone

Although these evidences point at the CBj receptors as an attractive target for the development of antianxiety therapies, the variable effects of exogenous cannabinoid agonists have shifted the interest of pharmacologists to an alternative 

In addition to the anxiolytic-like actions, EC deactivation inhibitors may also produce antidepressant-like effects (Patel and Hillard, 2006). Thus, AM404 decreased immobility time in the rat forced-swim test (Hill et al, 2005). 

Even more importantly, URB597 seems to lack hedonic properties, as it had no effect on two rat models of abuse potential, the conditioned place preference test and the drug discrimination test (Kathuria et al., 2003). Similar results have been recently obtained also in experiments with monkeys (Justinova et al., 2008). 

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