Enhancement evaluation

Irritation is veiy subjective and may differ widely from treatment to control subjects. Most irritation occurs as a result of penetration enhancers. Evaluation of toxicity and irritation should be concerned with mucosal tissue irritation, the extent of damage to the mucosal cells, and the rate of recovery. 

Burgalassi, S., et al. 2001. Cytotoxicity of potential ocular permeation enhancers evaluated on rabbit and human corneal epithelial cell lines. Toxicol Lett 122 1. 

Chetoni, P., et al. 2003. Ocular toxicity of some corneal penetration enhancers evaluated by electrophysiology measurements on isolated rabbit corneas. Toxicol In Vitro 17 197. 

Constantinides, P. P, Welzel, G., Ellens, H., Smith, P. L., Sturgis, S., Yiv, S. H., et al. (1996), Water-in-oil microemulsions containing medium-chain fatty acids/salts Formulation and intestinal absorption enhancement evaluation, Pharm. Res., 13(2), 210-215. 

Constantinides, P.P. Scalart, J.P. Lancaster, C. Mareello, J. Marks, G. Ellens, H. Smith, P.L. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm. Res. 1994, 77,1385-1390. 

Murakami T, Yoshioka M, Yumoto R. Topical delivery of keloid therapeutic drug, tranilast, by combined use of oleic acid and propylene glycol as a penetration enhancer evaluation by skin microdialysis in rats. J Pharm Pharmacol 1998 50 49—54. 

Saunders JCJ, Davis HJ, Coetzee L, et al. 1999. A Novel Skin Penetration Enhancer Evaluation by Membrane Diffusion and Confocal Microscopy. J Pharm Pharmaceut Sci 2(3) 99-107. http //www.ualberta.ca/ csps/JPPS2(3)/J.Saunders/microscopy.htm. 

VIEEW (Video Image Enhanced Evaluation of Weathering) is a digital macro scale image analysis system allowing objective, visual evaluations for applications such as automotive clearcoat analysis, texture analysis, delamination, chalking, and defect analysis [243]. VIEEW allows visualisation of chromatic and geometric information, optically defines surface defects, eliminates human subjectivity, and supplies reproducible quantitative data. In... 

Ultraviolet laser ablation Ultraviolet laser desorption/ionisation Ultraviolet photolysis Ultraviolet resonance Raman scattering/spectroscopy Video Image Enhanced Evaluation of Weathering Visible... 

Selection of the required unit operations Assignment of solvent destination Solvent recovery system Process enhancement Evaluation of flow sheet alternatives... 

Constantinides P, Welzel G, Ellens et al. 1996. Water-in-oil microemulsions containing medium-cheiin fatty acids salts formulation and intestinal absorption enhancement evaluation. Pharmaceutictil Research 210-215. 

A rmique approach to the hard chain equation of state has been developed by Hall and eoworkers (30). Flory s on-lattice particle insertion analysis is generalized to the off-lattice calculation. This theory is called the generalized Flory (GF) model. The enhanced evaluation of the insertion probability is further manipulated to yield the equation of state. 

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