Enhanced degradation agents

Peptides are present naturally in foods, arising mainly from the partial degradation of protein polypeptide chains. Some peptides, like the dipeptides carnosine, anserine, and balenine in vertebrate muscle or glutathione in fruits, are not proteinic in origin. In other cases, peptides are present in foods because they are used as additives (sweeteners, flavor enhancers, bulking agents in light drinks, etc.). 

Hill, C.M., Li, W.S., Thoden, J.B., Holden, H.M., Raushel, F.M. (2003). Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site. J. Am. Chem. Soc. 125 8990-1. 

Effect of Soil Disinfestation and Antimicrobial Agents on Enhanced Degradation... 

This basic combat logic may be enhanced by three additional functions (1) defense, which adds a notional ability to agents to be able to withstand a greater number of hits before having their state degraded, (2) reconstitution, which adds a provision for previously injured agents to be reconstituted to their alive state, and (3) fratricide ( or friendly fire), which adds an element of realism to ISAAC combat by making it possible to inadvertently hit friendly forces. 

The concentrate derived from ultrafiltration is usually a thick colourless gel containing about 4-8% solids. This must contain an antimicrobial agent to inhibit microbial growth and biological degradation. The type of antimicrobial agent used depends on the particular application for the exopolysaccharide. For example, the nature of file antimicrobial agent is less critical for industrial applications, such as enhanced oil recovery, than for use in cosmetics. 

Hsp90 is a molecular chaperon required for the refolding of proteins in cells exposed to environmental stress. It contains an ATP-binding pocket in its amino terminus. Several natural products, for example radicicol (230) (Scheme 48), bind to this pocket and inhibit its chaperon function, which is mirrored in enhanced proteosomal degradation of Hsp90 client proteins, so that compounds like 230 are of interest as novel anticancer agents. 

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