Energy metabolism in brain

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Some tissues are mainly energy suppliers, and others are mainly energy consumers. Still other tissues are important both as consumers and as suppliers. In this section we survey energy metabolism in five well-characterized vertebrate tissues Liver, adipocytes, striated muscle, smooth heart muscle, and brain. 

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Energy Metabolism in the Brain Leif Hertz cmd Gerald A. Dienel... 

Another important difficulty in the evaluation of the correct activity values for enzymes involved in energy metabolism in neurons resides in the fact that opposite processes may occur simultaneously, like the reduction of neuronal metabolism and compensatory enhancement in glial activity. The altered activities of some glycolytic enzymes in brain homogenates represent a net-effect, and it is unclear how the energy state (ATP level) of the neurons is perturbed if the metabolic activation is... 

Astroglial contribution to brain energy metabolism in humans revealed by 13c nuclear magnetic resonance spectroscopy Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 22 1523-1531. 

Hoyer S (1992) Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases. Mol Chem Neuropathol 16 207-224... 

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Fig. 6.16. Electrophoretic separation of serum creatine kinase enzymes from a normal healthy adult and from a patient who had a myocardial infarction 24 hours previously. Creatine kinase catalyzes the reversible transfer of a phosphate from ATP to creatine to form phos-phocreatine and ADP. The reaction is an important part of energy metabolism in heart muscle, skeletal muscle, and brain. Three different forms of the dimer exist BB (or CK-1) found in brain, MB (or CK-2) found only in heart, and MM (or CK-3), found only in skeletal and heart muscle (cathode, — ve anode, +ve).

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