Endotoxic principle

Almost 40 years ago, Westphal and Liideritz postulated that the lipid A component constitutes the endotoxic principle that is responsible for the... 

Lipid A is the endotoxic principle of Gram-negative bacteria lipopolysaccharide. Its structure varies between bacteria. Sepsis could equally also be classed as immunomodulatory. 

Another example of the special lipid classes present in M. tuberculosis is methylglucose lipopolysaccharides. Characterization and analysis of methylglucose lipopolysaccharides, with bacterial lipopolysaccharides in general, were extensively reviewed [13], in which a wide variety of MS-based apphcations that were implemented to the structural elucidation of lipopolysaccharides were covered. Special description given in the review was the tandem mass spectrometric methods and protocols for the analyses of lipid A, the endotoxic principle of lipopolysaccharides. It is advised that advanced readers should look for the details from this invaluable review article [13],... 

Jilg S, Barsig J, Leist M, Kiisters S, Volk H-D, Wendel A (1996) Enhanced release of interleukin-10 and soluble tmnor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock. J Pharmacol Exp Ther 278 421-431... 

Taken together, these data are consistent with the concept of several inflammatory principles (active oxygen species, cyclo-oxygenase and lipoxygenase products and PAF) working together to produce the manifestations of endotoxic shock and organ failure. 

---