Endoplasmic reticulum, calcium expression

The smooth endoplasmic reticulum calcium pumps (SERCA) found in brain were first identified in sarcoplasmic reticulum. The three isoforms of SERCA are products of separate genes SERCA-1 is expressed in fast-twitch skeletal muscle SERCA-2a in cardiac/slow-twitch muscle SERCA-2b, an alternatively spliced form, is expressed in smooth muscle and non-muscle tissues SERCA-3 is... 

Tavadia, S., Authi, K. S., Hodgins, M. B., and Munro, C. S., 2004, Expression of the sarco/endoplasmic reticulum calcium ATPase type 2 and 3 isoforms in normal skin and Darier s disease. Br J Dermatol, 151 440-5. 

Brouland, J. P., Gelebart, P., Kovacs, T., Enouf, J., Grossmann, J. and Papp, B., 2005, The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis. Am J Pathol 167, 233-42. 

Waldron, R. T., Short, A. D., Meadows, J. J., Ghosh, T. K. and Gill, D. L., 1994, Endoplasmic reticulum calcium pump expression and control of cell growth. J Biol Chem 269, 11927—33. 

Raeymaekers L, Verbist J, Wuytack F, Plessers L, Casteels R 1993 Expression of Ca2+ binding proteins of the sarcoplasmic reticulum of striated muscle in the endoplasmic reticulum of pig smooth muscles. Cell Calcium 14 581-589... 

Ryanodine receptors (RyR) mediate the release of calcium from intracellular stores of the sarcoplasmic/endoplasmic reticulum (SR/ER) following a small calcium influx via voltage-gated calcium channels of the cytoplasmic membrane after depolarization. The process, referred to as calcium-induced calcium release, triggers muscle contraction after electrical excitation in mammalian cardiac as well as in insect striated muscles (I). Three RyR isoforms exist in mammals Type 1, which is predominantly expressed in skeletal muscles Type 2, which is expressed in cardiac muscle and the more ubiquitously expressed Type 3 2 . 

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