Endometrial cancer phytoestrogens

The pattern of hormonal risk factors involved in the development of endometrial cancer is similar to those associated with the development of breast cancer. In addition, there is substantial evidence to suggest that HRT can increase the risk (Beral et al, 1999 Bingham et al, 1998). Compared to the UK, the incidence of endometrial cancer in countries such as Japan is relatively low (Bingham et al, 1998). It has been suggested that dietary factors may be responsible for the reduced incidence, and there is indirect evidence from epidemiology studies which suggests that increased consumption of soy products may lower the risk of endometrial cancer. However, these data are not conclusive. To date, no studies have demonstrated a link between consumption of phytoestrogens and an increased risk of endometrial cancer. 

Bandera EV, Williams MG, Sima C, et al. Phytoestrogen consumption and endometrial cancer risk a population-based case-control study in New Jersey. Cancer Causes Control. 2009 20 1117-1127. 

Lof M, Weiderpass E. Epidemiologic evidence suggests that dietary phytoestrogen intake is associated with reduced risk of breast, endometrial, and prostate cancers. Nutr Res. 2006 26 609-619. 

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