Endocrines and the kidney

Pituitary extracts contain some basic protein which may interfere with heparin. Although ACTH and heparin have similar effects on endocrine weight, body weight, protein metabolism, lipid metabolism, sludged blood, anaphylaxis, dispersibility phenomena, and peripheral eosinophilia , heparin prevents the eosinopenia and lymphopenia due to ACTH and corti-sone . It has no effect on the depletion of adrenal ascorbic acid by ACTH, sodium salicylate, adrenaline or histamine, or by cold exposure . In contrast, protamine blocks the depletion of adrenal ascorbic acid by ACTH. 

The hypotensive effect of heparin in hypertension has characteristics which make it different from other hypotensive agents, and also different from other biological effects of heparin. Keller reported that prolonged treatment with heparin (100 units/kg subcutaneously, three times weekly) 

---