Endocarditis acute renal failure

Thrombotic thrombocytopenic purpura is a rare acute or subacute disease in adults, rather similar to the hemolytic uremic syndrome in children, in which there is systemic malaise, fever, skin purpura, renal failure, hematuria and proteinuria. Hemorrhagic infarcts caused by platelet microthrombi occur in many organs in the brain they may cause stroke-like episodes (Matijevic and Wu 2006) although more commonly there is global encephalopathy. The blood film shows thrombocytopenia, hemolytic anemia and fragmented red cells. The differential diagnosis includes infective endocarditis, idiopathic thrombocytopenia, heparin-induced thrombocytopenia with thrombosis, systemic lupus erythematosus, non-bacterial thrombotic endocarditis and disseminated intravascular coagulation. 

Roth spots Endocarditis Acute intrinsic renal failure—acute glomerulonephritis... 

Complications recorded in a recent outbreak involving 147 symptomatic cases of Q fever included 2 of acute endocarditis, 2 of renal failure, and 1 of reactive polyarthropathy.65 Persistent nonspecific symptoms, such as fatigue and malaise, were reported in 32% of the patients in this series, while weight loss (defined as > 7 kg) was identified in 71%, although none developed serologic evidence... 

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