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Endocannabinoids biosynthesis

The lipid messenger OEA links dietary fat intake to satiety. CellMetab. 8, 281-288. Simon, G. M., and Cravatt, B. F. (2006). Endocannabinoid biosynthesis proceeding through glycer-ophospho-jV-acyl ethanolamine and a role for alpha /beta-hydrolase 4 in this pathway. J. Biol. [Pg.55]

Fig. 4. Chemical structures of inhibitors of endocannabinoid biosynthesis or inactivation... Fig. 4. Chemical structures of inhibitors of endocannabinoid biosynthesis or inactivation...
To establish transgenic mice lacking functional genes for endocannabinoid biosynthesis, and to study their phenotype... [Pg.172]

To develop selective and potent inhibitors of endocannabinoid biosynthesis and of 2-AG degradation that can be used in vivo... [Pg.172]

Parkinson s disease (PD) 1. In a non-human primate model of PD endocannabinoid levels are elevated in the basal ganglia and may contribute to the generation of parkinsonian symptoms and/or to expression of levodopa-induced dyskinesia. The cerebrospinal fluid of untreated PD patients contains elevated levels of AEA 1. CB-) antagonists or biosynthesis inhibitors... [Pg.467]

All the foregoing pharmacological effects of anandamide, in conjunction with the well-documented existence of specific systems for its biosynthesis, catabolism, and cellular reuptake to be discussed shortly, suggest that anandamide is indeed the endogenous cannabinoid ligand. The other two less studied A -acylethanolamide endocannabinoids and also 2-AG may serve similar functions. The differential roles of each of these four endocannabinoids are still unclear. [Pg.104]

Di Marzo V, Bisogno T, De Petrocellis L, Melck D, Orlando P, Wagner JA, Kunos G. Biosynthesis and inactivation of the endocannabinoid 2-arachido-noylglycerol in circulating and tumoral macrophages. Eur J Biochem 1999 264 258-267. [Pg.128]

Figure 10.6. The biosynthesis of endocannabinoids. Biosynthetic pathways for the biosynthesis of the major endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG). Note that the enzymes N-acyltransferase in anandamide biosynthesis. The biosynthesis of 2-AG can proceed via two different routes and is also dependent on an increase in Ca. Figures reprinted from Piomelli (2003) with permission from Nature Publishing Group. Figure 10.6. The biosynthesis of endocannabinoids. Biosynthetic pathways for the biosynthesis of the major endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG). Note that the enzymes N-acyltransferase in anandamide biosynthesis. The biosynthesis of 2-AG can proceed via two different routes and is also dependent on an increase in Ca. Figures reprinted from Piomelli (2003) with permission from Nature Publishing Group.
Biosynthesis of NADA and other endocannabinoids more questions than answers... [Pg.8]

Regulation of endocannabinoid levels what is the target, biosynthesis or degradation ... [Pg.14]

Bisogno T, Berrendero F, Ambrosino G, Cebeira M, Ramos JA, Fernandez-Ruiz 11, Di Marzo V (1999a) Brain regional disti ibution of endocannabinoids implications for their biosynthesis and biological function. Biochem Biophys Res Commun 256 377-380... [Pg.18]

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See also in sourсe #XX -- [ Pg.105 ]



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Endocannabinoid

Endocannabinoids

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