Encephalomyelitis viral causes

SOME IMPORTANT VIRAL CAUSES OF ENDEMIC ENCEPHALOMYELITIS... 

A number of animal diseases caused by viruses involve primary demyelination and often are associated with inflammation. These diseases are studied as animal models, which may provide clues about how a viral infection could lead to immune-mediated demyelination in humans [1, 5, 6]. Canine distemper virus causes a demyelinating disease, and the lesions in dog brain show a strong inflammatory response with some similarities to acute disseminated encephalomyelitis in man [ 1 ]. Visna is a slowly progressive demyelinating disease of sheep caused by a retrovirus [ 1 ]. 

Iron is more toxic than is commonly believed large oral doses of ferrous sulfate cause hepatic necrosis in Man within 48 hours (Luongo and Bjornson, 1954). The toxic action of encephalomyelitis virus, which is rich in iron, has been ascribed to viral transport of this metal across the blood-brain barrier which is normally impervious to it (Racker and Krimsky, 1947). 

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