Encephalitis, experimental allergic

The genes of the inducible and the constitutively expressed forms of NOS have been cloned and expressed. The expression of inducible NOS in the brain tissue of animals with experimentally induced neurological disorders (boma disease virus and rabies virus in rats), herpes simplex virus (mice) and experimental allergic encephalitis (in rats) suggests that NO produced by induced NOS may be a toxic fector in the pathogenesis of neurological diseases (Koprowski et /., 1993). 

Anti-CD40L, in experimental models, also inhibits graft-versus-host disease (149) and experimental allergic encephalitis (150) and may find use also in the human counterparts of those models. 

EAE experimental allergic/autoimmune encephalitis is an animal model for demyelinating diseases, such as multiple sclerosis. It is induced by injection of myelin basic protein or whole CNS tissue together with adjuvants. 

The effect of berbamine on experimental allergic encephalitis (EAG) was investigated in Lewis rats. Amelioration of the acute-phase of EAE was only minimal, but the incidence of relapsing EAE was reduced by 65% for berbamine at a non-toxic treatment dosage of 60 mg/kg via gavage on alternate days. These results suggest that berbamine, and perhaps other bisbenzylisoquinoline alkaloids, may have a potential role in the therapy of progressive multiple sclerosis [189]. 

The effect of tetrandrine on experimental allergic encephalitis (EAE) was investigated in Lewis rats. Amelioration of the acute-phase of EAE was only minimal, but the incidence of... 

Experimental allergic encephalitis (EAE) obtained by injection of myelin basic protein (MBP)... 

It has been well established that a number of chemokines including, KC, IP-10, MIP-1 a, RANTES, MARC (murine MCP-3), and TCA-3 (murine 1-309) are upregulated during the course of murine experimental allergic encephalitis (EAE) a mouse model of multiple sclerosis (MS) (25). Glabinski et al. have also demonstrated that the chemokines... 

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