Enantiomeric composition compounds analysis

One of the most exciting and recently emerging areas in asymmetric synthesis is asymmetric amplification. This topic has extraordinarily broad implications from mechanistic insights provided by non-linear effects to the enhancement of enantiomeric composition of important compounds to new hypotheses for the origin of biomolecular homochirality. The final chapter by Henri Kagan and David Fenwick provides a thorough and insightful analysis of the basic principles of asymmetric amplification and illustrations of some of the more important applications in synthesis. 

Capillary column gas chromatography has proved to be a suitable technique for the determination of the enantiomeric composition of chiral compounds in trace amounts. The gas chromatographic resolution of chiral substances can be achieved either by separation of enantiomers on an optically active stationary phase (1 ) or by formation of diastereoisomeric derivatives and analysis on a non-chi-ral phase (2). ... 

By using high resolution capillary gas chromatography, the scope of use of these reagents, which were initially introduced for NMR-analysis (5J and for GC separation of secondary alcohols (6), was enlarged considerably (7,j3). The application of these methods to the analysis of optically active compounds formed during microbiological processes and to the determination of the enantiomeric composition of chiral aroma constituents in some tropical fruits is described in this paper. 

Health authorities worldwide have fixed purity requirements for active pharmaceutical ingredients (APIs). When applied to chiral drugs, this implies that, if one enantiomer is chosen to be developed and marketed as an API, the counterpart isomer will be considered an impurity. The rule affects new chemical entities (NCEs) and chiral dmgs previously commercialized as a racemic mixture chiral switches). Therefore, techniques to perform the analytical control of the enantiomeric composition, at any of the drug development steps, together with processes to produce enantiomeric compounds with the desired enantiomeric purity, are essential in this domain. Liquid chromatography using chiral stationary phases (CSPs) is applied at two levels, analysis and production of enantiomerically pure compounds. At present, it can be considered the most universal technique for enantiomer separation. 

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