Emericella variecolor

From a marine-derived strain of the fungus Emericella variecolor, varitriol 26, varioxirane 27, dihydroterrein 28, and varixanthone 29 were found. In the NCI s 60-cell panel, 26 displayed potency toward selected renal, CNS, and breast cancer cell lines. 29 showed anti-microbial activity. Studies toward the total synthesis and absolute configurational determination of (+)-26 were achieved. ... 

In the extract of fungus Emericella variecolor, derived from the marine sponge Haliclona valliculata, two new natural products, evariquinone 41 and isoemericellin 42, were isolated. Compound 41, which also can be obtained from terrestrial fungus, showed anti-proliferative activity towards KB (60% inhibition) and NCI-H460 cells (69% inhibition) at a concentration of 3.16 mg mL... 

Two new sesterterpenes, 6-epi-ophiobolin G 49 and 6-epi-ophiobolin N 50, were isolated from the extraets of the fungus, Emericella variecolor GFIO obtained from marine sediment/ These eompounds showed cytotoxicity against the neuroblastoma cell line, Neuro 2A. 

Shimalactone A 79, a novel polyketide having bicyclo[4.2.0]octadiene and oxabicyclo[2.2.1]heptane units, was isolated from a cultured marine fungus of Emericella variecolor GFIO. Shimalactone A 79 induced neuritogenesis at 10 mg/mL against neuroblastoma Neuro 2A cells. At higher concentration of 20 mg/mL, it showed cytotoxicity against the same cell line. 

Numerous new polyketides were characterized in Emericella variecolor, Penicillium terrestre and Trichoderma reesei from the Bay of Gokasyo (Japan), the Bay of Qingdao... 

Taken from the sponge Haliclona valliculata harvested on the Island of Elba, at a depth of 20-30 m, the fungus Emericella variecolor produces in culture several anthraqui-none derivatives including evariquinone, an original molecule which is antiproliferative for KB cells, with an IC50 of 3.16[xgml (Bringmann et al, 2003). 

Wei, H., Itoh, T., Kinoshita, M., Kotoku, N., Aoki, S., and Kobayashi, M. (2005) Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GFIO. Tetrahedron, 61, 8054-8058. 

The labelling studies described above provide definitive evidence for the mixed polyketide-terpenoid biogenesis of the andibenins, andilesins, andi-tomins, austin and terretonin. The formation of the bicyclo [2.2.2] octane system in the first two classes of metabolite provides a rare example of a biosynthetic Diels-Alder reaction. The biosynthetic relationship of austin and andibenin was supported by the isolation of austin from another mutant strain of A. variecolor [81]. Further metabolites related to austin have been isolated from Emericella dentata [82] and Penicillium diversum [81]. Other complex metabolites which are almost certainly further products of the meroterpenoid pathway are fumiga-tonin (102) and paraherquonin (103) which have been isolated from Aspergillus... 

Aspergillus ustus Aspergillus variecolor Penicillium diversum Emericella denlata... 

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