Elixir Pediatric

This is a stable solution of digoxin specially formulated for oral use in infants and children. Each milliliter contains 50 meg (0.05 mg) digoxin. The lime-flavored elixir contains the inactive ingredients alcohol 10%, methylparaben 

1% (added as a preservative), citric acid, D C green no. 5, D C yellow no. 10, flavor, propylene glycol, 

---

Elixirs are sweetened hydroalcoholic oral solutions that are specially formulated for oral use in infants and children. Digoxin, a non-ionizable cardiotonic glycoside, is practically insoluble in water and is solubilized in propylene glycol, 10% ethanol, flavor, sweetener, preservative, and buffers to 50pg/ml in Lanoxin Elixir Pediatric from which the oral bioavailability of digoxin is 70-85%. Phenobarbital, an anticonvulsant and sedative with an intrinsic water solubility of 1 mg/ml, is solubilized in water, 23% ethanol, glucose, sodium saccharin, and flavors to 3.5 mg/ml in Donnatal Elixir. 

Binary 40% Propylene glycol and 10% Ethanol PEG/propylene glycol Lanoxin Elixir Pediatric (Digoxin) Ghildren s Tylenol Cold (Acetaminophen, chlorpheniramine maleate, and dextromethorphan)... 

Usual Digitalizing and Maintenance Dosages for Pediatric Elixir in Children with Normal Renal Function Based on Lean Body Weight ... 

Ethanol has been used traditionally as a cosolvent for oral solutions. It has been incorporated with sucrose in elixir formulations, the alcoholic content of which may vary from 3-78%. These formulations resulted in solubilization and/or stabilization of various drugs and have more favorable taste as compared to that of other solvents. Its use is often undesirable, however, in oral preparations intended for pediatric patients or other patients who cannot tolerate the effects of ethanol. Ethanol may also accentuate the saline taste of ionic... 

Most oral formulations are solid tablets or capsules, but there are many solution formulations for oral administration that are filled into capsules, or are bulk solutions such as oral solutions, syrups, and elixirs. The reasons for pursuing a solubilized oral formulation include enhancing the oral bioavailability of a poorly water-soluble drug, a drug molecule that is an oil, a low dose drug (i.e., pediatric formulation, a measurable formulation for dose modification, a formulation for patients who cannot swallow tablets... 

Patients having outpatient surgical procedures who experience moderate to moderately severe pain are frequently prescribed an oxycodone product as soon as oral intake is possible. The drug has high oral bioavailability and is well absorbed as either a tablet or elixir. Oxycodone oral solution is particularly useful to treat post-operative pain in children in the outpatient setting. Like many drugs used for children, oxycodone has not been approved for pediatric use by the FDA. 

---