Electrospun scaffolds synthesis

Zinn M, Witholt B, EgU T (2001) Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev 53 5-21 Zong X, Bien H, Chung C-Y, Yin L, Fang D, Hsiao BS, Chu B, Entcheva E (2005) Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials 26 5330-5338... 

Scientists have fabricated scaffolds in a two-step approach that combines an in situ coprecipitation synthesis route with the electrospinning process to prepare a novel type of biomimetic nanocomposite nanofibres of HA/CHT. The electrospun composite nanofibres of HA/CHT, with compositional and structural features close to the natural mineralised nanofibril counterparts, are of potential interest for bone TE. The results of HA/CHT indicate that although an initial inhibition occurs, the nanofibrous scaffolds which contained HA, as compared to scaffolds of CHT alone, appeared to have significantly stimulated the bone forming ability as shown by the cell proliferation, mineral deposition, and morphological observations, due to the excellent osteoconductivity of HA [19, 34, 56, 70]. 

Methods used for preparing of poly(ester urethane)-urea scaffolds are electro-spinning, solvent casting/salt leaching, phase inversion, laser excimer, and thermally induced phase separation. Electrospun poly (ester urethane)-ureas are elastomeric and the synthesis method allows control of fiber diameter, porosity, and degradation rate. All these properties aid in the development of soft tissue scaffolds. However, electro-spinning produces fibers with unacceptably small pore sizes. Thermally induced phase... 

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