Electrospun PHA Tissue-Engineering Scaffolds

Another promising potential of PHA in medical field is for the fabrication of scaffold as an ideal structure that can replace the natural extracellular matrix (ECM) until the host cells can repopulate and resynthesize a new natural matrix. 

Electrospinning of PHA is still relatively new in scaffold fabrication. To date, P(3HB) and P(3HB-co-3HV) are the most common microbial polyesters to be electrospun into tissue-engineering scaffolds. Suwantong et al. (2007) prepared ultrafine electrospun fiber mats of P(3HB) and P(3HB-co-3HV) as scaffolding materials for skin and nerve generation, hi their study, they evaluated the in vitro biocompatibility of these fibers using mouse fibroblasts and Schwann cells 

PHBV Nonwoven scaffold TE In vitro Schwann cell culture, cytotoxic evaluation, 3-(4.5-dimethylthiazol-2-yl) (Mi l ) assay (Suwantong et al. 2007) 

2 PHBV, hydroxyapatite (HA)/PHBV Nonwoven, aligned scaffold TE (SEM) (Tong and Wang 2007) 

3 PHBV, PHBV-PLLA, PHBV-PLGA Nonwoven scaffold TE SEM, oxygen plasma treatment, flucvescence microscc y. Mi l assay (Ndreu et al. 200 ) 

---