Electrophoretic mobility, of platelets

Like the blood vessel wall, blood cells (red cells, white cells, platelets) also exhibit negative charge densities on their surfaces. A wide variety of studies have been conducted which shows the effects of chemicals on the electrophoretic mobilities of blood cells (see Section 3.3). It is interesting to state in this section that Yazamaki and co-workers " showed using the Laser Zee meter that the electrophoretic mobilities of platelets are 1.441 ... 

Figure 25. Percentage change in electrophoretic mobility of platelets from control values as a function of concentration of (i) ADP and (ii) noradrenaline. ...

Figure 24. Effect of aspirin on electrophoretic mobility of human platelets in plasma.

The relatively high incidence of thromboembolic phenomena in women on the pill prompted an examination on the effects of the estrogenic and/or progesteronic components in the pill on the surface charge characteristics of the vascular system. Electrophoretic mobilities of erythrocytes and platelets and blood coagulation times were determined with samples of blood drawn from 33 women on the pill and 30 control subjects. The electrophoretic mobilities were reduced thrombin recalcification times were not affected but thrombin times and partial thromboplastin times were shortened. 

Kim, et al., ( ) have utilized radioiodinated (I proteins to measure adsorption of individual proteins and protein mixtures on LTI carbon surfaces. Their results indicate a very rapid adsorption of albumin onto the LTI carbon surface, consistent with Kim s model of blood interactions via a platelet-adhesion mechanism (.8). Microcalorimetric and electrophoretic mobility studies of protein adsorption on LTI carbon surfaces have been done by Chiu, et al., ( 5). The extension of the adsorbed protein layers have been directly measured by Fenstermaker, et al., ( ) and Stromberg et al., 7) at NBS using ellipsometric methods. 

In vitro and in vivo streaming-potential measurements in canine blood vessels (carotid arteries) showed that there is a significant increase in the negative surface charge density with infusion of heparin (Figure 22). Incubation of platelets with heparin causes an increase in electrophoretic mobility and therefore of the zeta potentials at the platelet-electrolyte interface. The relation between sulfonic acid content and antithrombogenic activity has been... 

Bray, B. A., and Alexander, B., 1%9, Progressive cleavage of sialic acid from platelets and their electrophoretic mobility. Blood 34 523. 

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