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Electrochemistry-mass spectrometry

The MOR is a surface-sensitive reaction [Clavilier et al., 1981a]. The influence of surface crystallography on the partitioning between the direct and the indirect pathways was investigated by Housmans and co-workers using electrochemistry, mass spectrometry, and modeling [Housmans et al., 2006 Housmans and Koper, 2003]. [Pg.547]

Jurva, U., Wikstrom, H. V., and Bruins, A. P. (2000). In vitro mimicry of metabolic oxidation reactions by electrochemistry/mass spectrometry. Rapid Commun. Mass Spectrom. 14 529-533. [Pg.291]

Electrochemical oxidation reactions have been fonnd to mimic cytochrome P450 catalysed oxidation reaction to some extent, and can therefore be used as a tool in performing preliminary drug metabolism studies. Combined electrochemistry-mass spectrometry was explored for drug metabolite studies [77-78],... [Pg.279]

Jurva U, Wikstrom HV, Weidolf L, et al. Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions. Rapid Commun Mass Spectrom. 2003 17(8) 800-810. [Pg.120]

Getek TA, Korfmacher WA, McRae TA, et al. Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen. / Chromatogr. 1989 474(l) 245-256. [Pg.120]

The reviews listed below are general reviews in the field. In addition, there are specific review serials devoted to advances in areas such as chromatography, electrochemistry, mass spectrometry, and many others. [Pg.1053]

Permentier, H. P, Bruins, A. P, and Bischoff, R., Electrochemistry-mass spectrometry in drug metabolism and protein research, Mini Rev. Med. Chem., 8 (1), 46, 2008. [Pg.227]

Karst, U., Electrochemistry/mass spectrometry (EC/MS)-a new tool to study drug metabolism and reaction mechanisms, Angew. Chem. Int. Ed. Engl., 43 (19), 2476, 2004. [Pg.227]

R2 P. V. Balaji, Contribution of C-H... n Interactions to the Affinity and Specificity of Carbohydrate Binding Sites , Mini-Rev. Org. Ghent., 2011, 8, 222. R3 A. Baumann and U. Karst, Online Electrochemistry/Mass Spectrometry in Drug Metabolism Studies Principles and Applications , Expert Opin. Drug. Met. Toxicol., 2010, 6, 715. [Pg.21]

Seiwert, B Henneken, H Karst, U. (2004) Ferrocenoyl Piperazide as Derivatizing Agent for the Analysis of Isocyanates and Related Compounds Using Liquid Chro-matography/Electrochemistry/Mass Spectrometry (LC/EC/MS). J. Am. Soc. Mass Spectrom. 15 1727-1736. [Pg.137]

From an electrochemical point of view, ES-MS might be viewed as a means to monitor the products of a controlled-current electrolysis on-line with mass spectrometry. Carrying out electrochemistry/mass spectrometry (EC/MS) in this fashion requires only a very small amount of sample and provides the molecular weight, and potentially the structure (e.g., via tandem mass spectrometry experiments), for the ionic products of the reactions. Given an experiment for which controlled-current electrolysis is suitable, " utilizing the inherent electrochemistry of ES would be expected to be much simpler than combining discrete electrochemical cells on-line with ES-MS for the same purpose. ... [Pg.116]

The information power of electrochemistry can be expanded by coupling it with methods which can determine the chemical identity of intermediates and products of electrode reactions. In-situ information can be obtained by on-line spectroscopic methods such as ultraviolet/visible (UV/vis) thin-layer spectroelectrochemistrys. Recently, effective on-line coupling of an electrochemical cell with a mass spectrometer has been demonstrated and its application to the study of biological redox reactions has been described . Electrochemistry/mass spectrometry as well as off-line methods were used in determining redox and related chemical reactivity of purine drugs. [Pg.310]

Overall electrochemical oxidation pathways of 6-thioguanine, an active drug, and 6-thioxanthine, an inactive metabolite, were evaluated by combination of electrochemistry, mass spectrometry and UV/vis spectro-scopy " . The thio group of both compounds can be oxidized at moderate potentials. From cyclic voltammetry, coulometry, UV/vis spectroscopy recorded during and after electrochemical oxidation, and mass spectrometry of the isolated products, it was determined that the immediate product of 6-thioguanine oxidation must be a radical which forms a disulfide in a rapid following dimerization reaction. The proposed oxidation pathway " is shown in Figure 2. [Pg.314]

On-Line Electrochemistry Mass Spectrometry in the Study of Redox Reactivity of Purine Drugs... [Pg.317]

The feasibility of on-line electrochemistry mass spectrometry in the study of electrode processes has recently been demonstrated by Heitbaum et al. . We have tested the potential of on-line mass spectrometry in the study of redox reactivity of biological compounds with uric acid as a probe. Electrochemical oxidation of uric acid has been studied extensively . The scheme in Figure 6 shows the electrochemical oxidation pathway of uric acid and indicates intermediates and products which were identified by on-line electrochemistry thermospray mass spectrometry (EC/TSP/MS/MS) . In our studies, tandem mass spectrometry (MS/MS) was used to obtain structurally informative fragmentation patterns (daughter spectra) of standards for comparison to the mass spectra of intermediates and products obtained by EC/TSP/MS/MS. This, for example, allowed identification of allantoin through its characteristic daughter spectrum. It also allowed confirmation of the structural features of the intermediate, bicyclic carboxylic acid, which apparently forms from the imine alcohol in the oxidation of uric acid. The intermediates and products which were identified in this way are indicated in the scheme, and mass spectral results are summarized in Table 1. [Pg.318]


See other pages where Electrochemistry-mass spectrometry is mentioned: [Pg.290]    [Pg.290]    [Pg.229]    [Pg.142]    [Pg.102]   
See also in sourсe #XX -- [ Pg.310 ]




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