Electrochemical Nucleic Acid Biosensors Based on Hybridization Detection for Clinical Analysis

Electrochemical Nucleic Acid Biosensors Based on Hybridization Detection for Clinical Analysis 

Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, 

Identification of nucleic acid sequences especially in biological samples led to early diagnosis of many mutations, microbiological, and inherited diseases [1]. The detection of specific base sequences in human, viral, or bacterial DNA holds great importance in diagnosis of several diseases. Detection of infectious and inherited diseases at molecular levels provides reliable and early diagnosis. 

Traditional diagnostic methods for clinical analysis based on coupling of electrophoretic separations, radioisotope or fluorescent labeling are toxic and time consuming. Due to these labor-intensive methods these are not well suited for routine and rapid clinical analysis [2]. Recently, there have been major advances in DNA sequencing technologies [3]. Several methods including various 

Recently, some reports have indicated that electrochemical techniques in nucleic acid biosensors are well suited for measuring hybridization event [10]. 

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