Electrical biosensor aptamer biosensors

Several electrical aptamer biosensors implemented the biocatalytic hydrolytic activities of thrombin, or the fact that proteins (e.g., thrombin) often include several binding sites for the formation of supramolecular complexes with different aptamers. The bioelectrocatalytic detection of thrombin by an electrical aptasensor was demonstrated by formation of an aptamer-thrombin complex on the electrode, followed by a thrombin-mediated hydrolysis of the nitroaniline-functionalized peptide, (22), yielding the redox-active product nitroaniline, (23), which was analyzed electrochemically76 (Fig. 12.20b). A further bioelectrocatalytic aptasensors configuration is depicted in Fig. 12.20c, where the multidentate formation of aptamer-protein supramolecular complexes was used to analyze thrombin.76 Thrombin includes two different binding sites for aptamers.77 One of the thrombin aptamers... 

The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticles and nanotubes nanomaterial-based electrochemical DNA detection electrochemical detection of microorganism-based DNA biosensor gold nanoparticle-based electrochemical DNA biosensors electrochemical detection of the aptamer-target interaction nanoparticle-induced catalysis for DNA biosensing basic terms regarding electrochemical DNA (nucleic acids) biosensors screen-printed electrodes for electrochemical DNA detection application of field-effect transistors to label-free electrical DNA biosensor arrays and electrochemical detection of nucleic acids using branched DNA amplifiers. 

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