Elastin drug delivery

Wright ER, Conticello VP. Self-assembly of block copolymers derived from elastin-mimetic polypeptide sequences. Adv Drug Delivery Rev 2002 54 1057-1073. 

Wu, Y., J.A. MacKay, J.R. McDaniel, A. Chilkoti, and R.L. Clark. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules 10(1) (2008) 19-24. 

Elastin-like polypeptides (ELPs) are another class of synthetic biopolymers that consist of a repeating pentapeptide sequence that is represented in native elastin. The peptide sequence in ELPs is VPGXG, where X is any amino acid, except proline. ELPs are water soluble and can form micron- or sub-micron-sized aggregates moreover, they are biocompatible and nonimmunogenic, which in turn make it useful as a potent drug delivery system. ... 

Megeed, Z., Cappello, J. and Ghandehari, H. (2002) Genetically engineered sUk-elastin-Uke protein polymers for controlled drag delivery. Advanced Drug Delivery Reviews, 54,1075-1091. 

Kim W, Chaikof EL (2010) Recombinant Elastin-Mimetic Biomaterials Emerging Applications in Medicine. Adv. drug delivery rev. 62 p. 1468-78. 

Massodi I, Bidwell GL, Raucher D (2005) Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery. J Controlled Release 108 396-408... 

Finally, temperature-sensitive, elastin-like peptide-modified dendrimers were synthesized for drug delivery by Kojima et al. [ 140]. Elastin is one of the major components of the extracellular matrix with temperature sensitivity. A repeat sequence of Val-Pro-Gly-Val-Gly was used to prepare the elastin-like peptide, which was conjugated to a PAMAM dendrimer G(4). The synthesized elastin-mimetic dendrimer-based polymer proved to be a potent drug carrier with both temperature- and pH-responsive properties. The same group reported fine-tuning of the temperature sensitivity by manipulation of the peptide chain length and the generation of dendrimer. 

C. Kojima, and K. Irie, Synthesis of temperature-dependent elastin-Uke peptide-modified dendrimer for drug delivery. Biopolymers, 100 (6), 714-21,2013. 

Mcdaniel, J. R., Callahan, D. J., Chilkoti, A. (2010). Drug delivery to solid tumors by elastin-Uke polypeptides. Advanced Drug Delivery Reviews, 62, 1456-1467. 

Elastin-like polypeptides (ELPs) are thermoresponsive biopolymers with a broad range of biotechnological applications including tissue engineering, drug delivery, biosensing, and protein purification [118, 119]. like PNIPAAm, ELPs also... 

Poly(elastin), another poly(peptide), is also being examined in both the medical and controlled release areas.20-32 Although this material is relatively new, and of synthetic origin, it could probably find utility in cosmetics. Other important poly(peptide) applications include their use as drug carriers,23 and biodegradable drug delivery systems.24... 

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