Eicosanoid renal effects

The pathophysiological effects of PG cannot readily be isolated from those of many other hormones and factors which regulate the haemodynamic, tubular and endocrine functions of the kidneys. It is clear that renal PG play a central role in water metabolism and renin release, whereas the effect of PG on transepithelial transport and the pathogenetic potential of other eicosanoids, such as leukotrienes, have not been fully explored. In addition, recent studies have supported the concept that enhanced generation of the vasoconstrictor, TXA2, is prominent in many experimental models of... 

Examining the incorporation of CLA into subcellular fractions of healthy and cancerous renal and testicular tissues, respectively, further differences were observed. For kidney, the CLA content was found to be significantly increased in the plasma membrane fraction of RCC in comparison to healthy renal tissue (0.21 0.06% and 0.33 0.18%, respectively) (Fig. 12.2). This result is of importance, as Belury (48) suggests the anticarcinogenic effect of CLA associated with a change in membrane composition which may ultimately affect events such as oxidative stress, eicosanoid... 

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