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Ehrlichs Major Ideas

Ehrlich s biographer observes that the theme of different functionalities on different parts of the same molecule runs throughout his work [18]. Another example that Ehrlich gave is the interaction of light with a molecule. He observed [Pg.114]


It has subsequently been shown that mercaptopurine is first metabolised by the enzyme hypoxanthine phosphoribosyl transferase into thioinosine monophosphate and this then acts as an inhibitor of de novo purine biosynthesis. Mercaptopurine worked even in patients whose leukaemia cells had become resistant to the effects of methotrexate, suggesting that combination chemotherapy with the two drugs might extend the period of remission from disease. The idea of combination chemotherapy to delay induction of resistant strains of microorganisms had, it will be recalled, been suggested by Ehrlich in around 1912. With leukaemia, it was the major breakthrough that was needed to achieve long-term survival in the disease. [Pg.171]


See other pages where Ehrlichs Major Ideas is mentioned: [Pg.114]    [Pg.114]    [Pg.114]    [Pg.165]    [Pg.153]    [Pg.81]    [Pg.336]    [Pg.1331]    [Pg.718]   


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Ehrlich

Ideas

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