Efficacy design

AH implantable medical devices ate complex in design, materials, and implementation procedures. The biocompatibiUty, biodurabiUty, and efficacy of medical devices are the subject of extensive research by biomaterials scientists, device manufacturers, and health care professionals. 

Methylpyrazole has been investigated as a possible treatment for alcoholism. The stmcture—activity relationship (SAR) associated with a series of pyrazoles has been examined ia a 1992 study (51). These compounds were designed as nonprostanoid prostacyclin mimetics to inhibit human platelet aggregation. In this study, 3,4,5-triphenylpyrazole was linked to a number of alkanoic acids, esters, and amides. From the many compounds synthesized, triphenyl-IJT-pyrazole-l-nonanoic acid (80) was found to be the most efficacious candidate (IC g = 0.4 //M). 

To remain safe and efficacious on the eye, contact lenses must maintain clear and wetted surfaces, provide an adequate supply of atmospheric oxygen to and adequate expulsion of carbon dioxide from the cornea, allow adequate flow of the eye s tear fluid, and avoid excessive abrasion of the ocular surface or eyeflds, all under a variety of environmental conditions. The clinical performance of a contact lens is controlled by the nature of the lens material the lens design the method and quaUty of manufacture the lens parameters or specifications prescribed by the practitioner and the cleaning, disinfection, and wearing procedures used by the patient. 

Depending upon the design criteria of the installed suppression system, an unsuppressed explosion overpressure of around 7 to 10 bar is reduced to a suppressed reduced explosion overpressure which lies in the range of Fred,max = 0-2 to 1 bar. Thus, vessels need to be explosion resistant for an overpressure of maximum 1 bar (ISO Standard 6184/4, Explosion Protection Systems Paii 4 Determination of Efficacy of Explosion Suppression Systems, Geneva, 1985). 

Rational design, 148-149, 152 Real-time assays, 83, 88 Receptor(s). See also Drug receptors affinity for, 6, 63 allosteric model of, 143 Clark s work, 3 classical model of, 44-45 concept of, 2-4 conformations, 13-14, 13 Of conservation equation for, 76 constitutive activity of, 49-51 coupling of, 27 definition of, 2 desensitization of, 34 efficacy for, 6... 

In the USA, LTRAs have largely replaced theophylline as the incremental drug for the treatment of moderate and severe asthma, where LABA plus ICS alone do not provide adequate control. For patients with mild persistent asthma, LTRAs have been designated as a suitable substitute for low dose ICS by the National Asthma Education Panel Program (NAEPP) of the National Heart and Lung Institute (National Institutes of Health). However, inhaled ICS are more efficacious. 

Nelfinavir is a nonpeptidic, rationally designed HIV protease inhibitor. Nelfinavir has demonstrated efficacy in both monotherapy and in combination with the reverse transcriptase inhibitors stavudine (d4T) or zivudine + 3TC. The major side effect is mild to moderate diarrhea. 

The Efficacy of an Alternative Instrnctional Programme Designed to Enhance Secondary Stndents Competence in the Triplet Relationship... 

---