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Prostacyclin mimetics

Methylpyrazole has been investigated as a possible treatment for alcoholism. The stmcture—activity relationship (SAR) associated with a series of pyrazoles has been examined ia a 1992 study (51). These compounds were designed as nonprostanoid prostacyclin mimetics to inhibit human platelet aggregation. In this study, 3,4,5-triphenylpyrazole was linked to a number of alkanoic acids, esters, and amides. From the many compounds synthesized, triphenyl-IJT-pyrazole-l-nonanoic acid (80) was found to be the most efficacious candidate (IC g = 0.4 //M). [Pg.317]

Wise H, Jones RL. Focus on prostacyclin and its novel mimetics. Trends Pharmacol Sci 1996 17 17-21. [Pg.125]

See other pages where Prostacyclin mimetics is mentioned: [Pg.537]    [Pg.31]    [Pg.316]    [Pg.218]    [Pg.227]    [Pg.227]    [Pg.537]    [Pg.31]    [Pg.316]    [Pg.218]    [Pg.227]    [Pg.227]    [Pg.373]    [Pg.141]    [Pg.146]    [Pg.202]   
See also in sourсe #XX -- [ Pg.202 ]



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