Effervescent tablets evaluations

With regard to compressibility and compactibility, the considerations pertaining to raw materials in effervescent products are similar to the ones that prevail in evaluating raw materials intended for conventional tablets. However, poor compactibility cannot usually be compensated for by the use of binders, as this will prevent a rapid dissolution of the effervescent tablet. Addition of a binder is generally not as critical for the dissolution of effervescent granules or powders. 

Both chemical and physical properties have to be considered when evaluating effervescent products. In this review, only the physical properties will be discussed, except where the chemical characteristics are especially influenced by the effervescent base. For more detail, Ph. Eur. includes a special disintegration test for effervescent tablets and granules. ... 

The stability of three commercial effervescent and one dispersible aspirin tablet were evaluated by factorially designed experiments. Temperature affected the hydrolysis of all tablets, whereas humidity influenced one product in a plastic tube and one in an aluminum tube. ... 

Swamy PV, Gada SN, Shirsand SB, Kinagi MB, Shilpa H. Design and evaluation of cost effective orodispersible tablets of diethylcarbamazine citrate by effervescent method. Int J Pharm Sci Res. 6 (1) 258-264,2010. 

---