Effervescent tablets acetylsalicylic acid

P. Merckle and K.A. Kovar, Assay of effervescent tablets by near-infrared spectroscopy in transmittance and reflectance mode acetylsalicylic acid in mono and combination formulations, J. Pharm. Biomed. Anal, 17, 365-374 (1998). 

The bioavailability of acetylsalicylic acid from three different dosage forms—two types of effervescent tablets with different buffering properties and tablets of a conventional type— was studied in healthy volunteers. Complete absorption was found for all the preparations studied. Both effervescent tablets were rapidly absorbed. The buffering properties did not influence the rate of absorption.f ... 

Conventional processing equipment (mixers, granulators, roller compactors, drying equipment, and mills) can be used to produce effervescent preparations if the influence of atmospheric moisture is considered. As a rule, tablet presses have to be adapted to handle effervescent products, except for tablets with a sufficient proportion of a self-lubricating substance, such as acetylsalicylic acid. 

Some effervescent tablet products are successfully produced by direct compression (e.g., acetylsalicylic acid products). Direct compression normally requires careful selection of raw materials to achieve a free-flowing, non-segregating, compressible mixture. Effervescent products present the same problems as conventional products in direct compression. 

Effervescent tablets are normally produced by machines with external lubrication systems. Most tablet machine manufacturers can add this type of equipment to their rotary machines. Products with a high proportion of acetylsalicylic acid can be manufactured without any traditional lubricants. Consequently, conventional rotary tablet presses can be used. Effervescent acetylsalicylic acid tablets are produced on ordinary high-speed rotary presses at the Pharmacia plant in Helsingborg, Sweden. 

Merckle and Kovar reported an assay of effervescent tablets (intact and powdered) by NIRS in transmittance and reflectance modes. Results of quantitative determination of acetylsalicylic acid (ASA) and ASA in combination with ascorbic acid and/or paracetamol were comparable in both transmittance and reflectance modes. Corti and associates described a NIR transmittance analysis of coated tablets, using both whole and milled tablets. 

Acetylsalicylic acid (ASA) can be administered in tablet form, as effervescent powder, or injected systemically as its lysinate. Following a single dose of 0.5-1 g, ASA... 

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