Effects of Methyldiphenyltin Chloride MDPTC on Human NK Cell Function

6 Effects of Methyldiphenyltin Chloride (MDPTC) on Human NK Cell Function Effects on Lytic Function 

In contrast to TMTC and DMPTC, exposure of NK cells to MDPTC for 1 h caused very significant decreases in NK lytic function at both 5 and 2.5 pM (Table 4.5.6). Exposure to 200 and 100 nM MDPTC 

The ability of NK cells to bind to K562 tumor cells was unaffected by exposure to MDPTC for 24 and 48 h. However, a 6 d exposure to as low as 100 nM MDPTC decreased the binding capacity of NK cells by about 40% (Table 4.5.6).  

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