Effects of Exposure to Jet Fuels and Kerosene in Experimental Animals

EFFECTS OF EXPOSURE TO JET FUELS AND KEROSENE IN EXPERIMENTAL ANIMALS 

Several animal inhalation toxicity studies have been conducted on various jet fuels (summarized in Table 4-2). In one study, male F344 rats were exposed to shale-oil-derived JP-4 continuously for 90 days by inhalation at 1,000 mg/m3. The exposure resulted in no effects on lung volumes, dynamic resistance and compliance, quasistatic compliance, partial and full forced vital capacities, carbon monoxide diffusion capacity, and closing volume. There 

Fuel Type Species or Cell Line Exposure Concentration Exposure Duration Effects Reference 

JP-8 F344 rats, C57BL/6 mice 500, 1,000 mg/m3 (vapor) 90 days No respiratory tract effects attributed to JP-8 results well characterized with regard to concentration and chemical composition Mattie et al. 1991 

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