Effects of Dimethylphenyltin Chloride DMPTC on Human NK Cell Function

5 Effects of Dimethylphenyltin Chloride (DMPTC) on Human NK Cell Function 

Exposure of NK cells to DMPTC for 1 h caused no significant decreases in cytotoxic function at any concentration (1-10 pM) (Table 4.5.5). However, a 24 h exposure to 10 pM DMPTC caused a 98% decrease in the capacity of NK cells to lyse tumor cells and 2.5 pM DMPTC for 24 h decreased NK lytic function by 52%. A 48 h exposure significantly decreased the ability of NK cells to lyse tumor cells at concentrations as low as 1 pM (45%) and a 6 d exposure to 1 pM decreased lytic function by 84% (Table 4.5.5).  

Exposures of NK cells to 10, 5, or 2.5 pM DMPTC for 24 h caused no change in binding function. Likewise, 48 h exposures caused no decrease in binding function at 5 or 2.5 pM DMPTC. However, a 6 d exposure to DMPTC caused significant decreases in binding function (80%) at the 2.5 pM concentration (Table 4.5.5). i 

---