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Ecstasy SSRIs

MAOIs, monoamine oxidase inhibitors MDMA, methylenedioxy-methamphetamine (ecstasy) SSRIs, selective serotonin reuptake inhibitors. Serotonin Syndrome and Similar Syndromes... [Pg.359]

Overdose of moclobemide by itself rarely appears to give rise to serious problems. This is in contrast to overdose with conventional monoamine oxidase inhibitors, which can cause fatal 5HT toxicity. However, if patients take moclobemide together with serotonergic antidepressants, such as SSRIs or clomipramine, 5HT toxicity is common. 5HT toxicity occurred in 11 of 21 patients who took overdoses of moclobemide and serotonergic agents but in only one of 33 patients who took moclobemide alone (13). Consistent with this, four patients died, presumably of 5HT toxicity, after co-ingesting 3,4-methyle-nedioxymethamphetamine (MDMA, ecstasy) and moclobemide (14). [Pg.4]

An MDMA-related psychiatric adverse effect ecstasy been enhanced by an SSRI (107). [Pg.47]

Methylenedioxymethamphetamine (MDMA) The psychological effects of MDMA ( Ecstasy ) are markedly reduced by the concurrent use of citalopram. It seems likely that other SSRIs will also reduce or block the effects of MDMA. An isolated report describes a neurotoxic reaction in a man on citalopram when he took unknown amounts of MDMA. [Pg.2471]

The study of ecstasy with citalopram was primarily undertaken to find out how eestasy works, but on the basis of these results and animal studies it seems likely that patients already taking citalopram may not be able to get as high on usual doses of ecstasy, and some adverse effects may also be redueed. Furthermore, if the proposed mechanism of interaction is correct, the same is also likely to be true if they are taking any other SSRI and some cases have been reported. However, be aware of possible pharmaeokinetie interaetions with some SSRIs that are potent CYP2D6 inhibitors (e.g. fluoxetine, paroxetine), which may increase ecstasy levels. There is also a risk of increased serotonergic activity and there have been a few reports of interaetions involving other sympathomimetics and SSRIs or related drugs, see Phentermine + Fluoxetine , p.205. [Pg.202]

A neurotoxic reaction has also been reported with ecstasy and citalo-pram, see Amfetamines and related drugs + SSRIs , p.201. [Pg.205]

Ecstasy (MDMA methylenedioxymethamfetamine). For comments on the effects of SSRIs on the metabolism of ecstasy and the possibility of increased serotonin effects, see Amfetamines and related drugs + SSMs ,... [Pg.1225]


See other pages where Ecstasy SSRIs is mentioned: [Pg.191]    [Pg.47]    [Pg.88]    [Pg.597]    [Pg.611]    [Pg.103]    [Pg.2298]    [Pg.2305]    [Pg.34]    [Pg.201]    [Pg.201]   
See also in sourсe #XX -- [ Pg.201 ]




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