Ecothiopate

CjHjoNOjPS 3147-20-4) see Ecothiopate iodide phosphorus trichloride (C1-,P 7719-12-2) see Isoflurophate phosphoryl chloride... 

PROCAINE ECOTHIOPATE t plasma concentrations and risk of unconsciousness, and cardiovascular collapse with injections of prilocaine Ecothiopate inhibits pseudocholinesterase, which metabolizes prilocaine Do not co-administer. Use an alternative local anaesthetic not subject to metabolism by pseudocholinesterases... 

Adrenaline (— brown), benserazide (— brown), bitoscanate, captopril, carbi-dopa (— brown), carbimazole, disuliiram, dobutamine (— brown), ecothiopate, iso-etharine (— brown), levodopa (— brown), methallibure, methimazole, polythiazide, rimiterol, thiacetazone, thiopentone... 

Econosone, 918 Ecostatin, 579 Ecostigmine iodide, 579 Ecothiopate iodide, 579 Ecoval, 393 Ectasule Minus, 584 Ecuagesico, 598, 733 Edecril, 591 Edecrin(e), 591 Edrol, 596... 

Glaucoma is a disorder of vision accompanied by an increase in ocular pressure. Although mostly replaced by other drugs (e.g., beta blockers and pilocarpine), anti-ChE drugs such as ecothiopate are still used in the treatment of these common disorders. 

A number of types of parasympathomimetics are used. Muscarinic agonists used include carbachol and pilocarpine (see MUSCARINIC CHOLINOCEPTOR agonists) ANTICHOLINESTERASES include demecarium bromide, dyflos, ecothiopate iodide, pl sostigmine sulphate and pyridostigmine bromide. 

Ecostatin econazolenitrate, ecothiopate ecothiopate iodide, ecothiopate iodide [ban, inn] (echothiopate diethoxyphosphinylthiocholine Ml 217 Camsilon Phospholine Iodide ) is an irreversible (organophosphate group) ANTICHOLINESTERASE. It is a PARASYMPATHOMIMETIC used topically as a miotic in ANTIGLAUCOMA TREATMENT. 

Phospholine Iodide" - ecothiopate iodide. PHOSPHOLIPASE INHIBITORS act at sites on phospholipases, a large group of enzymes with many roles. There are two main groups of enzyme of particular interest in relation to receptor signalling, which makes them important drug targets phospholipase Aj and phospholipase C. These will be discussed in turn. 

As mentioned earlier, these agents were discovered before their mechanism of action was known. Once it was known that they acted on the cholinesterase enzyme, compounds such as ecothiopate (Fig. 11.57) were designed to fit the active site more accurately. 

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